Abstract
Pathological Complete Response (pCR) after neoadjuvant chemotherapy (NAC) is a surrogate marker of a good prognosis. However, we treated a rare case of cerebellar metastasis after the patient achieved pCR. A 78-year-old woman was referred for an indistinct mass in the right breast and palpable axillary lymph nodes. The mass was 2.8 cm in diameter and was diagnosed as invasive ductal carcinoma, nuclear grade 1, ER-negative, PgR-negative, and HER2 3+. NAC was started ; paclitaxel and trastuzumab were given. A modified radical mastectomy was performed after chemotherapy was finished, and on pathology, Complete remission was documented.
One year after surgery, the patient developed nausea and dizziness ; a large metastatic tumor was found in the left cerebellar hemisphere. The patient received 39 Gy irradiation to the cerebellar and was given chemotherapy (capecitabine and lapatinib). To date, the metastatic lesion has been well controlled during 22 months from the recognition of brain metastasis, of follow-up.
