Abstract
A 53-year-old woman had a large ulcer on the right breast. She was diagnosed as having triple-negative scirrhous carcinoma and metastases to the right supraclavicular lymph nodes and bilateral axillary lymph nodes. The patient received 4 cycles of FEC (5-FU 500 mg/m2, epirubicin 100 mg/m2,cyclophosphamide 500 mg/m2) and 4 cycles of DOC (docetaxel 75 mg/m2) as primary chemotherapy. This therapy resulted in the complete disappearance of the breast tumor and marked shrinkage of local, regional and distant lymph nodes. The patient underwent a modified radical mastectomy and contralateral axiliary dissection. On pathology, the complete disappearance of cancer cells in the breast tumor and all dissected lymph nodes was noted. After surgery, the patient received postmastectomy radiation therapy to the right chest wall and supraciavicular lymph nodes. The patient has been well without any relapse for 20 months. In breast cancer patients with distant metastasis, local therapy after systemic therapy may be a useful approach for good responders to systemic therapy.
