Abstract
A 59-year-old woman was detected having a ridging lesion at the greater curvature of the pyloric antrum on a gastric x-ray examination at a medical checkup. Gastric endoscopy revealed a submucosal tumor of the stomach and she was referred to our hospital. Ultrasonic endoscopy showed a well demarcated submucosal tumor with a tessellated center part and a very rich blood supply in the proper muscle layer. A fine needle biopsy cytology revealed solid proliferation of comparatively homogeneous tumor cells which had small oval-shaped nuclei and lightly eosinophilic cytoplasm. On immunohistochemistry, the tumor cells were partly positive for synaptophysin and chromogranin A. Neuroendocrine tumor was suspected. Distal gastrectomy with lymph node dissection was performed under laparotomy. Histopathology revealed sheet-like proliferation of tumor cells which had comparatively homogeneous round nuclei and distinctly outlined cell boundaries. The tumor cells were positive for α-SMA, laminin and type IV collagen, and negative for cytokeratin, desmin and neuroendocrine marker. The final diagnosis was glomus tumor of the stomach.
