Abstract
A case of radiation-induced breast angiosarcoma that developed following breast-conserving surgery is reported. The patient was a 53-year-old woman who presented with chief complaints of pain and subcutaneous ecchymosis in the left papillary region. She had undergone breast-conserving surgery and radiation therapy to the residual breast for breast cancer of the left breast seven years earlier. The skin in the left breast had thickened and hardened, and ultrasound examination showed small hypoechoic regions dispersed directly below the papilla, while magnetic resonance imaging (MRI) revealed densely-stained areas with irregular margins. Ultimately, secondary angiosarcoma was diagnosed based on resection biopsy. Mastectomy was performed, but because local recurrence was seen at an early stage, repeat surgery (wide resection) was performed. Paclitaxel was administered as postoperative adjuvant therapy, but because bone metastasis was observed four months later, it was switched to pazopanib, which was discontinued after four months because it was no longer effective. It is necessary to recognize radiation-induced secondary angiosarcoma as a rare but important late complication in patients who have undergone breast-conserving surgery.
