Abstract
Two cases of matrix-producing carcinoma (MPC) of the breast are presented. Case 1 : A 51-year-old woman complained of a mass palpable in the left breast. Left breast cancer (T2N0M0, stage IIA) was diagnosed, and mastectomy and sentinel lymph node biopsy were performed. The histological diagnosis of the excised specimen showed pT2N0, MPC, and sn0/2, and indicated that the tumor was negative for estrogen and progesterone receptors and human epidermal growth factor receptor 2. Four courses of chemotherapy with taxotere and cyclophosphamide were administered postoperatively. Fifty-two months after the operation, the patient is alive and recurrence free. Case 2 : A 48-year-old woman complained of a mass palpable in the left breast. Left breast cancer (T1N0M0, stage I) was diagnosed, and partial mastectomy and sentinel lymph node biopsy were performed. The histological diagnosis of the excised specimen showed pT2N0, MPC, and sn(0/4), and indicated that the tumor was negative for estrogen and progesterone receptors and human epidermal growth factor receptor 2. The patient was administered 4 courses of adjuvant chemotherapy with epirubicin and cyclophosphamide plus bevacizumab followed by bevacizumab monotherapy for 1 year. Twelve months after the operation, lung, bone, and liver metastases were diagnosed. The chemotherapy regimen was changed to weekly paclitaxel ; however, the patient's condition deteriorated, and she died 18 months after the operation.
