Abstract
A 78-year-old woman was diagnosed as having intestinal obstruction due to transverse colon cancer and underwent colectomy at our hospital. The pathological diagnosis was moderately differentiated adenocarcinoma, SE, ly1, v1, N0(0/7), H0, P0, M0, Stage II. The risk of recurrence was high, and postoperative adjuvant chemotherapy with capecitabine was started. The patient was admitted to our hospital because of febrile neutropenia (Grade 2), diarrhea (Grade 3), and stomatitis (Grade 3). Antibacterial drugs with granulocyte-colony stimulating factor improved febrile neutropenia, but the persistent enterocolitis resulted in septic shock. The dihydropyrimidine dehydrogenase (DPD) activity of the peripheral blood mononucleocytes was remarkably low at 11.8 U/mg protein. Low DPD activity was diagnosed.
