Abstract
Objective : To identify prognostic factors among preoperative data of routine blood examinations in patients with Stage II/III colorectal cancer (CRC).
Methods : Prospectively recorded data from 907 patients with Stage II/III CRC who underwent R0 resection between January 2003 and March 2013 were evaluated. Preoperative data of routine blood examinations, age, sex, tumor location, histological grade, stage, and postoperative adjuvant chemotherapy (PAC) were analyzed to investigate their relationships with relapse-free survival (RFS) using univariate and multivariate analyses.
Results : Univariate analyses for RFS showed significant differences in tumor location, histological grade, Stage, PAC, and mean corpuscular volume (MCV). Multivariate analysis for RFS showed significant differences in stage (p<0.0001) and MCV (p<0.0057) ; MCV <80 fl was associated with favorable RFS compared with MCV 80-100 fl [HR = 0.49 ; 95% CI = 0.30 - 0.77 ; P =0.0014]. Patients with MCV <80 fl had significantly better RFS than those with MCV ≥80 fl in Stage II (p=0.002).
Conclusion : MCV was a significant predictor of RFS in patients with Stage II CRC who underwent R0 resection.
