A Case of Asynchronous Double Cancer of the Liver Consisting of Cholangiolocellular and Hepatocellular Carcinoma in the Background of Chronic Hepatitis B

Abstract

An 82-year-old male patient was diagnosed with a tumorous lesion in the liver during a clinical observation for chronic hepatitis B. Abdominal MRI showed a lesion in segment 8 of the liver that was enhanced in the early phase and not clearly washed out. CT during arterial portography (CTAP) revealed an area in segment 8 where portal blood flow diminished. CT hepatic arteriography (CTHA) showed early enhancement but revealed no washout in the late phase. The preoperative diagnosis was atypical hepatocellular carcinoma (HCC), and the patient underwent partial hepatectomy. Based on histopathological and immunohistochemical findings, the tumor was diagnosed as cholangiolocellular carcinoma (CoCC). Four months after the resection, a lesion in segment 7 of the liver was detected. The preoperative diagnosis was recurrence of CoCC, and the patient underwent partial hepatectomy. Histologically, the tumor showed HCC.

Sometimes CoCC and HCC developed asynchronously.