A Case of a Breast Lesion due to IgG4-related Disease Diagnosed with Eyelid Swelling

Abstract

A 71-year-old woman visited our ophthalmology department due to left eyelid swelling and was diagnosed with a left orbital tumor on MRI. The patient was diagnosed with IgG4-related disease by tumor biopsy. CT tomography revealed a high-absorption area with a contrast-enhanced effect in the inner upper area of the left mammary gland. Breast ultrasonography revealed a local hypoechoic region at this site. Core needle biopsy revealed advanced plasma cell and lymphocyte infiltration, and IgG4-related mastitis was diagnosed. After the start of steroid treatment, improvement in ocular symptoms and a decrease in blood IgG levels were observed. The breast lesions also reduced over time, and at four years after the start of the observation, no recurrence was observed.