THE JOURNAL OF JAPAN SOCIETY FOR CLINICAL ANESTHESIA
Online ISSN : 1349-9149
Print ISSN : 0285-4945
ISSN-L : 0285-4945
Symposium (3)
The Present State of Use of Recombinant Activated Factor Ⅶ (rFⅦa : NoboSeven®) in Japan
Takao KOBAYASHI
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JOURNAL FREE ACCESS

2015 Volume 35 Issue 2 Pages 237-243

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Abstract
Postpartum hemorrhage remains the leading cause of maternal morbidity and mortality in Japan. Recombinant activated factor Ⅶ (rFⅦa) has been used off-label to treat life-threatening obstetrical bleeding, but the use of rFⅦa should be considered only when first-line treatment with a combination of blood products and surgical approaches fails to control bleeding. An initial dose of 90 µg/kg is administered intravenously within 2 to 5 minutes. Patients with higher fibrinogen (≥100 mg/dL) and platelet levels (≥50,000/μL) seem to respond better to rFⅦa. Since tranexamic acid is an antifibrinolytic agent, administration of rFⅦa combined with tranexamic acid might be a risk factor for thrombotic adverse events, so excessive use of tranexamic acid should be avoided.
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© 2015 by The Japan Society for Clinical Anesthesia
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