Propofol and PRIS during Perioperative Period “Don’t Use Propofol in Children” （From the Con Position）It’s OK to Use Propofol in Children

Abstract

Propofol Infusion Syndrome（PRIS）is a severe complication that occurs during propofol infusion that includes hepatomegaly, fatty liver, hyperlipemia, metabolic acidosis, rhabdomyolysis and myoglobinemia. Because PRIS cases were first reported in children, use of propofol for the purpose of sedation during artificial respiration in children has been contraindicated in Japan. PRIS possibly develops as a result of lowered ATP production due to the inhibition of mitochondrial function and fatty acid metabolism. PRIS appears more commonly in children because their metabolism and elimination of propofol are prolonged due to their higher dependency on fat metabolism. Safe application of propofol has been indicated as the precise mechanism of PRIS has become clearer.