Abstract
A full-term newborn infant, who showed drastic elevation of serum CPK, GOT and GPT, muscle rigidity of the both upper and lower extremities with contracture of the joints, and paralysis of the respiratory muscles on the 5th postoperative day for meningomyelocele, was presented. The baby was artificially ventilated through a nasotracheal tube for 26 days in ICU until recovery of the normal muscle function. Neither abnormal elevation of the body temperature nor pulmonary change was observed throughout the operation and admission in ICU.
Hypotrophy of the type I muscle fiber was found by muscle biopsy performed at 11th month of age. Abnormal embriological development in the early fetal life associated with the development of the meningomyelocele was suggested as the cause of abnormal muscle rigidity and CPK elevation.
