Abstract
Objective : We clarified cytology in metaplastic changes recognized in endometrial glandular and stromal breakdown (EGBD).
Study Design : Materials involved 32 cases of EGBD, 38 of disordered proliferative phase (DPP), 49 of NPE, 34 of SH, and 29 of CH concerning (1) the frequency of metaplastic cells, (2) the frequency and proportion of metaplastic clumps with irregular protrusions (MCIP), (3) the frequency of MCIP with condensed stromal clusters, and (4) immunostaining of CD10 for condensed stromal clusters in MCIP.
Results : Metaplastic cells were seen in 93.8% of EGBD cases. MCIP was seen in 90.6%, consisting of 16.1% of epithelial cell clusters. MCIP with condensed stromal clusters was seen in 93.1% of EGBD cases. All findings were significantly more frequently seen in EGBD cases than others. Condensed stromal clusters in MCIP were immunocytochemically positive for CD10.
Conclusions : Our findings indicate that the presence of MCIP, with condensed stromal clusters, is derived from papillary metaplasia occurring on endometrial surface epithelium. Cytological observation of these cells may be useful in providing the nature of EGBD endometrium.
