Abstract
Background : Central giant cell lesion (CGCL) is an uncommon tumor-like lesion, and most commonly affects the gnathic bone. We enconstered a case of CGCL of the mandible in an infant, and report the cytological features.
Case : A male infant presented with swelling of the cheek and fever. Computed tomography (CT) and magnetic resonance imaging (MRI) revealed a mass lesion in the left mandible. Positron emission tomography (PET) demonstrated 18F-fluoro-2-deoxyglucose (FDG) uptake in the left mandible. Malignant tumor of the mandible was suspected, and a lesion biopsy was performed under general anesthesia. Intraoperative stamp smear of the biopsy specimen showed tissue fragments and dispersed cells against a hemorrhagic and necrotic background. The tumor was composed of mononuclear cells, multinucleated giant cells and spindle-shaped fibroblastic cells admixed with collagen fibers and inflammatory cells, such as lymphocytes and neutrophils. CGCL was suspected cytologically, and surgical curettage of the lesion was performed. Finally, the diagnosis of CGCL was confirmed histopathologically.
Conclusion : It was possible to diagnose CGCL cytologically, and stamp cytology during surgery was useful in the present case.
