Abstract
Background : Extraovarian peritoneal serous papillary carcinoma (EOPPC), a rare condition featuring peritoneal carcinomatosis, uninvolved or minimally involved ovaries, and no identifiable primary tumors, has a histological pattern similar to ovarian serous papillary carcinoma.
Case : A 56-year-old woman with EOPPC and abnormal endometrial cytology changes, reported no specific symptoms. Endometrial cytology showed classV with enlarged atypical cell clusters and endometrial biopsy indicated endometrioid adenocarcinoma with suspected endometrial cancer. Total abdominal hysterectomy and bilateral salpingooophorectomy and lymph node resection showed no ascites or peritoneal dissemination. Washing ascites cytology showed many large malignant cells in small papillary clusters. Histopathological findings showed no malignant cells in the endometrium, but the left mesovarium and perimetrium showed small fragments of papillary adenocarcinoma. Both ovaries were normal in size, but the ovarian serosal surface was microscopically involved. Immunohistochemically, tumor cells were positive for p53 and MIB-1 but negative for calretinin, yielding a diagnosis of EOPPC.
Conclusion : Endometrial cytology is useful in diagnosing EOPPC.
