Pathological problems in The General Rules for Clinical and Pathological Management of Uterine Cervical Cancer (2^nd ed, 1997)

Abstract

Objectives : We reviewed pathological problems in General Rules for Clinical and Pathological Management of Uterine Cervical Cancer based on recent HPV developments and on the Bethesda system. We propose 3 new general rules on nomenclature and definitions for dysplasia/CIS system, glandular dysplasia, and microinvasive adenocarcinoma.
Conclusions : (i) In early squamous lesion nomenclature, the CIN system (CIN1, 2, 3) is recommended instead of the dysplasia/CIS system for histological diagnosis. (ii) The definition of glandular dysplasia should be clarified. (iii) Microinvasive adenocarcinoma criteria should be improved.