Abstract
Objective : To examine the clinical implications of atypical squamous cells of undetermined significance (ASC-US) in cytology of the uterine cervix.
Study Design : We examined the cases of ASC-US diagnosed in our hospital : a total of 12141 women who participated in the screening for cancer of the cervix between January 2010 and December 2011 were included in our study.
Results : Of the patients, 1.9% were found to have ASC-US, and 66% of these cases had evidence of infection with high-risk HPV. After one-year follow-up, CIN 1/2 was confirmed in 25/21% of the cases. In 14 of the 19 cases of CIN 1, atypical cytological features could not be detected at the follow-up. We treated 10 cases of CIN 2/3 and followed up 6 cases. Multivariate modeling identified only one factor affecting the risk of CIN, that is high-risk HPV infection.
Conclusion : The results of the multivariate analysis identified high-risk HPV infection in cases of ASC-US as an independent risk factor for CIN.
