Abstract
Background : We report herein on a case of breast cancer with solid tubular carcinoma together with squamous cell differentiation and secretory carcinoma.
Case : In a female in her 80 s, ultrasound imaging showed a right breast mass of 30 mm in diameter. Core needle biopsy and imprint cytology were performed. On the imprint cytology, against the background of the mucus, and appearing in loosely-coupled clumps, a large number of atypical cells were seen with unclear boundaries, oval nuclei, and coarse-fine granular nuclear chromatin. Atypical cells also appeared surrounding a plurality of mucus, marked mucus globular structures and signet ring like cells. Aggregation of mixed squamous and glandular cells was observed against the background of necrotic material. The tumor was determined to be malignant. At a later date, a right mastectomy was performed. The tumor was located in the C area, about 40% secretory carcinoma and 60% solid tubular carcinoma. The latter component demonstrated squamous cell differentiation. Breast cancer was diagnosed with solid tubular carcinoma together with squamous cell differentiation and secretory carcinoma.
Conclusion : Because some examples of breast cancer consist of different components, it would appear that a careful diagnosis based on a cytological diagnosis of the LBC specimen is essentially required, together with conventional methods.
