2016 Volume 55 Issue 4 Pages 239-244
Background : In the present study, we report a rare case of diffuse large B-cell lymphoma, spindle cell variant (Sp-DLBCL).
Case : The patient was a 50’s woman. She consulted our hospital because of the abdominal mass detected by CT at a nearby hospital. Malignant lymphoma was suspected based on the finding of multiple mesenteric lymph node swelling (1 to 4 cm in diameter) detected by CT and an increase of serum soluble IL-2-receptor. The lymph node was biopsied to make a diagnosis. In the cytological examination, malignant lymphoma was suspected, but histologic examination showed numerous atypical spindle shaped cells, being reminiscent of malignant mesenchymal neoplasm. Immunophenotypical analysis revealed CD20 and MUM-1 positivity, and CD10 and BCL6 negativity on the neoplastic cells. Our final diagnosis was made as Sp-DLBCL, non-GCB type. In the background, variable numbers of T-cells and macrophages were admixtured.
Conclusion : Sp-DLBCL is a very rare variant of malignant lymphoma and difficult to make a diagnosis histologically. In this case, cytological examination was useful tool, and it was very important for the pathological diagnosis to demonstrate the tumor cell origin immunophenotypically.
