2017 Volume 56 Issue 3 Pages 130-136
Objective : Reports on liquid based cytology of thyroid nodules using LBC PREP2 are still rare. The aim of this report was to clarify the cytological findings and diagnostic accuracy of liquid based cytology of thyroid nodules using LBC PREP2.
Study Design : We studied 887 thyroid nodules by fine needle aspiration cytology at our hospital from June 2011 to May 2015. We washed the aspirated needles with LBC PREP2 fixative and prepared the material as directed.
Results : The sensitivity and specificity of LBC using LBC PREP2 for the correct diagnosis in 204 cases in whom the results were comparable with the histological results were 98.0% and 89.3%, respectively. Most of the red blood cells were hemolyzed and their debris appeared in the prepared specimens. The appearance of colloid was different from that in the cytology specimens processed using SurePathTM. The basement membrane surrounding the follicular cluster was visualized in case of adenomatous goiter. Nuclear grooves and pseudoinclusions were more easily recognized than in the specimens prepared using ThinPrepTM.
Conclusion : LBC using LBC PREP2 is at least as useful as the other known LBC methods for thyroid nodules. Some cytological features were different from those observed in the specimens processed by other LBC methods.
