Case of an elderly male breast cancer patient in whom X chromosome was analyzed

Abstract

Herein, we report the case of an elderly male patient who was diagnosed as having invasive micropapillary carcinoma (IMPC) of the breast, focusing on the findings of cytology and X-chromosome analysis. The patient presented with a localized solid nodule in the right subareolar region. Cytology revealed cell clusters showing an inside-out pattern in a clean background. The margins of the cell clusters were partially fluffy or showed a microvilli-like pattern. Histologically, the tumor was a combination of invasive ductal carcinoma and IMPC. FISH assay revealed an increase in the number of X chromosomes in 32% of the tumor cells.