2025 Volume 64 Issue 3 Pages 121-129
Objective : The Sydney system was recently proposed for classifying and reporting the findings of fine-needle aspiration cytology in lymphadenopathy. We investigated the usefulness of the Sydney system in reporting the findings of imprint smear cytology.
Study Design : A total of 118 samples were re-evaluated and classified according to the Sydney system. At the first diagnostic level, we classified the samples into five categories (inadequate/insufficient, benign, atypical cells/atypical of lymphoid cells, suspicious, and malignant), based only on the cytomorphological findings. Samples were then reclassified using ancillary techniques at the second level. The percentages in each category at the two levels were calculated and compared between the two diagnostic levels. In addition, we sub-classified the lymphoma samples and evaluated the diagnostic agreement rates for each level.
Results : At the first diagnostic level, 57.6％ of the samples were classified as malignant. At the second diagnostic level, 85.1％ of the samples were classified as malignant. The percentage of samples diagnosed as malignant was significantly higher at the second level than at the first level (p＜0.01). The diagnostic agreement was 74.6％ for the first level and 83.6％ for the second level.
Conclusions : Imprint smear cytology is suitable for lymphoma diagnosis under the guidance of the Sydney system, and the diagnostic accuracy is high.
