2025 Volume 64 Issue 3 Pages 130-135
Background : Mixed squamous cell and glandular papilloma (MSCGP) is a rare benign tumor of the lungs, with few reports on its cytological features. Herein, we describe a case of MSCGP that was initially suspected as a case of mucoepidermoid carcinoma on cytological examination.
Case : A 60-year-old man with congestive heart failure was admitted to our hospital. A plain chest X-ray revealed an abnormal opacity in the left lung field, which subsequently showed a tendency towards enlargement. A chest computed tomography revealed a large mass measuring 5 cm in diameter and a transbronchial lung biopsy was performed. Cytologically, the tumor cells was composed of squamous-like cells and cells containing mucin. Keratinocytes were observed in the background. Based on these findings, we initially suspected mucoepidermoid carcinoma, but the final histopathological diagnosis was MSCGP.
Conclusion : When squamous cell-like cells and cells containing mucin are found together in lesions of the respiratory tract, the possibility of MSCGP should be borne in mind in addition to mucoepidermoid carcinoma. The presence of keratinocytes, papillary clusters, and linear columnar epithelial cells, which are characteristic findings of MSCGP, can be used to distinguish this tumor from mucoepidermoid carcinoma.
