Cytological Findings and Mitotic Index of Non-Hodgkin's Malignant Lymphoma

Using Lukes-Collins Classification

Abstract

Twenty-three cases of non-Hodgkin's malignant lymphoma were studied with referrence to Lukes and Collinsclassification. These cytological pictures were investigated in detail by using a touch smear method. The densityof nuclear pore in some cases was measured with freezefracture method and the relationship between mitotic indexand nuclear pore density was studied and discussed.Surface marker analysis of our cases showed that mostcases of these lymphoma were B cell type. Some of thecases were T cell or Null cell type lymphoma and one casewas a mixture of T cell and B cell types Follicular centercell origin (FCC) was found in 74% of the total cases andthey had B cell surface marker in all cases examined.
Most of them were large transformed type lymphoma. Allcases of convoluted type were T cell nature. Undefinedtypes decided in this series showed high degree of variationmorphologically and most of them were Null cell type.
There were no difference of mitotic index in nodular typeand the control cases. The mitotic index of the lymphomaof follicular center cell origin among diffuse type showed anincreasing number in this order, small cleaved, largecleaved, small transformed, large transformed, and immunoblastic sarcoma.
Our study using a freeze-fracture method showed goodcorrelationship between the density of nuclear pore andmitotic indices.