A Cytologic Study on Leiomyosarcoma

Abstract

A cytologic study in 9 cases with leiomyosarcoma wascarried out with several materials (vaginal smear 1, touchsmears 9, sputum1, pleural effusion 1, ascites 1) obtainedfrom various organs (uterine corpus 3, uterine cervix 1, stomach 1, duodenum 1, rectum 1, soft tissue 2).
Histologically, there were found the spindle cell type in 2cases, the pleomorphic type in 4 and the immature type in 3. The cytologic materials were examined by means ofhistologic methods for H-E, Giemsa, Azan, van Gieson, Masson's trichrome, PTAH, PAS, alcianblue stains, andadditionally by cell block and electrone-microscopic observation especially for the pleural effusion from cases withthe disease in uterine cervix. But there was no definitiveevidence of the cytoplasm of tumor cells in view ofmyogenic characteristics.Cytologic observation of leiomyosarcoma differed fromthe differentiation of the tumor. Spindle cells were foundpredominant in the mature type. The pleomorphic typewere revealed as multinuclear giant cells. The immaturetype were observed in a dense blue area in the poorcytoplasma by Papanicolaou stain, and revealed a densebody with myofilaments in similar areas under electronemicroscopic observation.