Abstract
Placental protein (=PP) 5, PP10, and PP12 were studied with the unlabelled antibody enzyme (PAP) technique in 10% formalin-fixed paraffin-embedded tissue specimens from 15 patients with cervical squamous cell carcinoma and from the cervical cancer xenograft.
Positive PP5, PP10, and PP12 staining were seen in 0%, 38.5%, and 50% of the non-malignant squamous epithelial cases, respectively.
Cervical cancer cells were subclassified into three different cell types; small cell, non-keratinizing large cell, and karatinizing cell types. Positive rate of PP5 and PP12 showed no significant difference in the three cell types of squamous cell cancers. But positive PP10 staining was seen in 7.1% of small cell type, 35.7% of nonkeratinizing large cell type, and 54.5 % of keratinizing cell type.
From these date, clinical applications of PP5, PP10, and PP12 were discussed.
