A cytomorphometrical study of early squamous cell carcinoma of the bronchus

its comparison with electron microscopic findings

Abstract

Brushing cytologic findings of seventeen cases of resected early squamous cell carcinoma of the bronchus were studied cytomorphometorically, and compared with light and electron microscopic findings.
With the increase of nuclear area, nuclear/cytoplasmic ratio and cellular atypia of the cancer cells in the upper and lower layer, there were greater tendency to invasion and increase of the cancer cells, where cytoplasmic processes and intercellular spaces were less well developed and the cells were mostly of clear cell type. A good rank correlationcoefficient was obtained.
Other cytomorphometric findings concerning keratinizing cells and nuclear area of the cells in each layer had also good correlation with light and electron microscopic findings.