1989 Volume 28 Issue 3 Pages 438-443
The cytopathologic findings are presented for five cases of adrenal pheochromocytoma. An immunoperoxidase staining technique was also employed in an effort to demonstrate endocrine granule constituents (EGC) in imprint smear as well as tissue sections. The cytology was characterized by tumor cells arranged predominantly in epithelial-like agrregate. The cells had relatively large amounts cytoplasm which was often finely granular. They also revealed multinucleation, cannivalism, vacuolization in many of the tumor cells. In smears as well as tissue section, EGC was immunocytochemically demonstrated intensively on the entire cytoplasm and also in the intranuclear vacuoles. At the ultrastructual levels, the endocrine granules were demonstrated in the cytoplasm of tumor cells with marked electron dense.
The study established the applicability of the immunoperoxidase method for EGC to this endocrine tumors, confirmed the increases accuracy of diagnoses with routine cellular samnles.
