The Journal of the Japanese Society of Clinical Cytology
Online ISSN : 1882-7233
Print ISSN : 0387-1193
ISSN-L : 0387-1193
Detection of human papillomavirus DNA in genital condyloma in women and their male partners by using in situ DNA hybridization
Ryo KONNO, Shinji SATO, Masayuki HORIGUCHI, Kazuo SHIKANO, Nobuo YAEGASHI, Atsushi ENDOH, Hidetoshi CHIBA, Akira YAJIMA
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Keywords: Vulva, cervix and penis, Condyloma acuminatum, HPV (human papillomavirus), In situ DNA, DNA hybridization, Sexual partner
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1990 Volume 29 Issue 6 Pages 851-857

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Abstract
Forma1in-fixed, paraffin-embedded biopsy samples of 16 vulvar condylomata, 6 cervical condylomata and 13 penile condylomata from male partners were analyzed for the presence of HPV-6/11 DNA by in situ hybridization using a biotin-labeled DNA probe (ViraType in situ). HPV-6/11 DNA was detected in 11 vulvar samples (68.6%), in 4 cervical samples (66.7%) and in 11 penile samples (84.6%).
Investigation of sexual partners revealed that seven of 12 couples (58.3%) shared HPV-6/11.
The signal intensity of the HPV DNA was generally strong in the superficial cell layers and weak in the parabasal or basal cell layers.
No malignant lesions resulted from the condyloma acuminatum caused by HPV-6/11. There was only mild dysplasia in both sexes.
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© The Japanese Society of Clinical Cytology
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