Abstract
Cytological features of endometrial carcinoma were quantitatively analysed, compared with endometrial hyperplasia and normal endometrium. A total of 39 cases, consisting of 19 cases of endometrial carcinoma (Grade 1), 10 of endometrial hyperplasia (adenomatous hyperplasia) and 10 of normal endometrium (5 proliferative phase and 5 secretory phase) were examined retrospectively.
This study revealed that values for both coefficients of variation (CV) of nuclear size and the distance between nuclei were large in endometrial carcinoma and small in normal endometrium. In endometrial hyperplasia, CV of the distance between nuclei was larger thanthat of nuclear diameter.
The other observed features of endometrial carcinoma were as follows ; high incidence of nucleoli or large nucleoli, many clusters, clusters with nuclei protruding from the margin, few co-existing normal clusters, multiple stratification and red blood cells on the background.
This study concluded that quantitative analysis was useful for cytodiagnosis of uterine endometrium.
