Cytologic and clinical findings of sclerosing stromal tumor of the ovary

Abstract

Sclerosing stromal tumor (SST) is an uncommon benign ovarian neoplasm principally occurring in young women. Although 91 cases of SST have been reported in the literature, the cytologic findings have not been described. A cases of SST in a 13-year-old Japanese girl is presented in this paper, and this is the youngest patient and the largest tumor. This neoplasm did not display hormonal activity and exhibited typical microscopic findings. The cytologic findings of SST are reported for the first time. Isolated, small cells without cytoplasm, having round or spindle-shaped nuclei with a thin nuclear membrane, finely granular chromatin, and single or double small nucleoli were found in the imprint cytology sample. Although SST can be pathologically differentiated from theca cell tumor and fibroma, prospective cytologic diagnosis of SST is considered difficult. The clinical features of 62 cases of SST are also described in detail based on a review of the literature.