Abstract
Using DNA in situ hybridization technique, we studied biopsied cervical specimens (carcinoma in situ: 44 cases, invasive carcinoma: 51 cases) for the localization, distribution, and frequency of detectable human papillomavirus (HPV) DNA.
1. In carcinoma in situ, HPV-DNA was detected in 61.4%(27/44).
2. In invasive carcinoma, HPV-DNA was detected in 49.0%(25/51).
3. As to the carcinoma cell type the detection rates of HPV-DNA in keratinizing and non-keratinizing types were 26.3%(5/19) and 62.5%(20/32), respectively.
4. As to the distribution type of positive in situ hybridization, both even and uneven distributions were common in carcinoma in situ, while the uneven type predomintel in invasive carcinoma.Further more, in only 2 cases (8.6%), the concentrated type was also found in the superficial layer.
