1996 Volume 35 Issue 2 Pages 118-125
We analyzed seventy-five cases of uterine cervical adenocarcinoma to clarify cytological findings. In addition, 25 of these cases were also analyzed for cytological differentiation using microscopic morphometry. Twenty-five patients, consisting of 12 with endocervical type (EC), 5 with endometrioid type, 4 with adenoma malignum and 4 with adenocarcinoma in situ, were compared with each other and with 20 benign cases (normal endocervical-cells). In principle, 100 malignant tumor cells and 50 normal cells from each case were measured in terms of the size of the nucleus (longitudinal dimension+transverse dimension/2), the roundness of the nucleus (longitudinal dimension/transverse dimension), the diameter of the nucleous (based on the largest nucleolus), the number of nucleoli and the irregularity of the nucleus and nucleoli.
The roundness of the nucleus was useful for differentiating between cervical adenocarcinomas and benign cases. Other morphometrical indices showed the possibility of differentiation between EC and other adenocarcinomas, but differentiation amoung the types of EC remained problematic. In addition to the cytological findings of each type on Pap. smear, it is potentially possible to clarify the differences among uterine cervical adenocarcinomas.
