A case of mtillerian adenosarcoma of uterine body

Abstract

Müllerian adenosarcoma of the uterus was first reported by Clement and Scully (1974). Histologically, this tumor was characterized as a mixture of benign epithelial and sarcomatous stroma.
A müllerian adenosarcoma was found in the uterine corpus of a 58-year-old woman. The tumor had originated from the posterior wall of uterine corpus. Cytologically, the tumor cells were seen to have little cytoplasm, nuclei were oval, and the chromatin was coarse granular. These cellular findings suggested that the tumor was a sarcoma. Histologically, the tumor was composed of both stromal and epithelial elements. The former elements were composed of large atypical cells with little cytoplasm and bizarre nuclei, and the latter were composed of proliferative-endometriumlike epithelium.
Immunohistochemically, myoglobin and desmine were positive in the stromal tumor cells. From these findings, the stromal cells were considered to be indicative of rhabdomyosarcoma. Thus, the final diagnosis of this tumor was müllerian adenosarcoma (heterologous).