Abstract
Objective: To assess the accuracy of endometrial cytology criteria, we focused on architectural atypism.
Study Design: Between January 1988 and December 1997, we samplied cell endocytes from the endometrial cavity directly smeared on glass slides, then fixed and stained with routine Papnicolaou staind. We analyzed the results of endometrial cytology in patients with endometrial carcinoma and atypical complex hyperplasia and the histological findings of patients with suspicious or positive cytology.
Results: Detection of endometrial carcinoma was 96.6% of 297 patients and of complex atypical hyperplasia, 81.8% of 22. False negative results numbered 4.7% of 129 with G 1 adenocarcinoma, 3.7% of 81 with G 2 adenocarcinoma, and 8.3% of 13 with carcinosarcoma. Endometrial cytology was diagnosed as suspicious or positive in 1, 955 and in 1, 324 of those cases endometrial biopsy was undertaken. We diagnosed 41 with endometrial carcinoma and 241 with endometrial hyperplasia in 1, 003 suspected cancer patients. Among 321 positive patients, 266 were diagnosed with endometrial carcinoma and 6 with endometrial hyperplasia.
Conclusion: Endometrial cytology is accurate and useful in screening for endometrial carcinoma and hyperplasia. Paying attention to architectural atypism is especially important when diagnosing endometrial cytology in such screening
