Abstract
Background: Uterine serous adenocarcinoma (USC) is a distinct histologic type of endometrial cancer associated with a high relapse rate and poor prognosis. We present the clinical findings, clinical courses and cytopathological findings of three cases of this disease. USC is characterized by grape-like or papillary formation, small nuclear size, and a high nuclear and cytoplasmic ratio. Psammoma bodies are present in 30% of cases.
Case: All of the cases were postmenopausal and their ages were between 56 and 77 (mean: 68.7). The chief complaint in all cases was abnormal genital bleeding. We observed the morphological features and measured the nuclear size of tumor cells. In each case, tumor cells had a high nuclearcytoplasmic ratio, intracytoplasmic vacuoles and a remarkable nucleolus. Tumor cells showed grape-like or papillary structures in all cases, and psamomoma bodies were seen in case 2. Round or oval-shaped nuclei were seen. The mean nuclear long axis length was 11.5±2.4 μm, and the nuclear short axis length was 10.4±2.0 μm.
Conclusion: Cytological findings are important in clinical diagnosis. Regardless of depth of muscle invasion, patients with USC frequently have extrauterine disease.
