2005 Volume 44 Issue 4 Pages 235-239
Background: We report a rare case of urothelial carcinoma of the renal pelvis with trophoblastic differentiation.
Case: A 59-year-old man with hematuria was found in retrograde pyelography, to have a tumor of the right renal pelvis. Cytological specimens of right pelvic washing consisted of papillary clusters and scattered atypical cells identical to urothelial carcinoma, and multinucleated giant cells with cytoplasmic vacuoles and mononuclear cells with large nuclei containing coarse chromatin. Histological examination of the tumor showed papillary urothelial carcinoma (grade 2 dominant) associated with syncytiotrophoblast-like giant cells. Multiple foci of giant cells and mononuclear cells were positive for hCG in immunohistochemistry.
Conclusion: Multinucleated giant cells in renal pelvic washing showed trophoblastic differentiation in urothelial carcinoma.
