Characterizing Disuse Edema Using Bioelectrical Impedance Analysis

~Comparison with Heart Failure and Lower Extremity Arterial Disease, and Relationship with Drug-induced Edema~

Abstract

　Purpose: This study aimed to evaluate the characteristics of patients with disuse edema, lower extremity arterial disease（LEAD）, or heart failure using bioelectrical impedance analysis（BIA）. We also aimed to evaluate the relationship between disuse edema and drug-induced edema.　Methods: Patients with disuse edema（n=17）, LEAD（n=25）, heart failure（n=48）, or drug-induced edema（n=16）underwent BIA to measure body fat mass, muscle mass, body fat percentage, and extracellular water to total body water ratio（ECW/TBW）. Blood samples were collected to evaluate variables such as CONUT score.　Results: Patients with disuse edema had a significantly higher body mass index, body fat percentage, and body fat mass. Patients with drug-induced edema had a significantly higher ECW/TBW than those with disuse edema. Multivariate analysis revealed that older age and higher CONUT score were independent risk factors for an ECW/TBW\_mls2265\/0.4.　Conclusion: Patients with disuse edema tended to be more obese than those with LEAD or heart failure. Patients with drug-induced edema have similar characteristics to those with disuse edema, but they are more edematous. High ECW/TBW, which is a marker of edema, is a risk factor for nutritional disorders in older people.