Six cases of head and neck osteosarcoma

Abstract

We present six patients with head and neck osteosarcomas. They ranged in age from 15 to 84 years with a median age of 63.5 years. There were five males and one female. The site of origin was the mandibular bone in four patients, the maxilla in one, and the larynx in one. Five patients were TNM stage ⅡA and one was stage Ⅲ. Histological findings revealed osteoblastic cancers in five patients and chondroblastic in one. All patients underwent surgical resection and adjuvant therapy was performed in five cases. Pathologically complete resections were obtained in five cases; however, only one patient was diagnosed with positive margins in the surgical specimen. In two cases, the cancer recurred, one locally at 2 months and the other by distant metastasis at 12 months. The case of local recurrence was non-responsive to preoperative chemotherapy and was stump-positive upon resection.