Two Cases of Laugier-Hunziker Syndrome

Abstract

Laugier-Hunziker-Baran syndrome （LHBS） is a rare disorder characterized by multiple and melanin hyperpigmentation of the lips and oral mucosa, often associated with pigmentation of the nails and fingertips. The two patients were elderly women, in whom pigmentation of the lips, buccal mucosa and fingers was confirmed. Advance of the pigmentation was observed during long-term follow-up survey of both cases. They were systemically healthy and had no family history of abnormal pigmentation. Differential diagnosis from Addison disease and Peutz-Jeghers syndrome was ruled out. It is necessary for oral clinicians to recognize this syndrome as one of the diseases that causes oral pigmentation to develop, and to distinguish it from other cases of abnormal pigmentation.