Abstract
Neuropathic pain is associated with hyperalgesia to noxious stimuli and allodynia, pain induced by tactile stimuli. Elucidation of mechanism of induction of allodynia is an intriguing issue from viewpoints of both basic research and pain management. Although sciatic nerve injury models have been employed for studies on neuropathic pain, we found that intrathecal administration of prostaglandin E2 induced allodynia as well as hyperalgesia. Here I report recent progress of molecular mechanism of neuropathic pain including studies with knockout mice.
