Abstract
DM-1 is the new enteral nutrition formula supplemented with L-Isoleucine to inhibit hyperglycemia. In this study, we investigated this possibility for 20 elderly patients with abnormal glucose tolerance. Their fasting glucose levels were from 110 to 150 mg/dL and all of them were totally tube-fed. The patients were randomized to receive either DM-1 or a standard formula for the initial week and crossover to another formula for another week. Blood glucose and insulin concentrations were measured on the last day with either formula. The highest average blood glucose level in DM-1 group was significantly lower than that in the standard formula group (DM-1: 139±11mg/dL, standard formula: 148±12mg/dL). The average plasma insulin level in DM-1 group was also lower than that in the standard formula group. The results indicate that DM-1 has a potential to help with the glycemic control of elderly patients with abnormal glucose tolerance and tube feeding.
