Impact of a LowGI/GL-Carbohydrate Liquid Formula vs. a modified-carbohydrate Liquid formula (LowGI) on 24-Hour Blood glucose variability (GV) on Type 2 Diabetic Patients as Assessed by Continuous Glucose Monitoring (CGM)

Abstract

[AIM] The impact of a low-carbohydrate (Low GI/GL) formula vs. a palatinose-based (low GI) formula fed via PEG tube on 24-hour GV were measured with CGM in patients with Type 2 diabetes.
[METHODS] Nine patients require PEG feeding tube registered to the study. All the patients had well controlled blood glucose and were monitored for 5 consecutive days. All the patients received standard formulas (SF) for one day as baseline data. Five subjects received the low GI/GL formula on day 2 and 3, a low GI formula on days 4 and 5, while the remaining 4 subjects received the same formulas but received low GI formula followed by the low GI/GL. All the subjects were fed on the standard feeing regimen with 3 or 4 doses for two-hours feeding throughout the study period.
[RESULTS] The 24-hour mean glucose levels in patients on SF, low GI/GL, and low GI formula were 128.3±37.4, 111.7±26.0, and 117.8±28.2 mg/dL, respectively. The magnitude of GV on low GI/GL formulas were lower than that of SF and low GI.
CONCLUSION : The low GI/GL formula and the low GI formula reduced GV compared to the SF, but GV was most reduced when fed with low GI/GL formula. The low GI/GL formula was thought to be effective to reduce GV and percent time of hyperglycemia and hypoglycemia in type 2 diabetic patients on enteral nutrition.