Fe-Ptナノ粒子とヒドロキシプロピルセルロースからなる熱応答性磁気キャリアの作製

抄録

The present paper describes a fabrication of magnetic composite of Fe-Pt nanoparticles and hydroxylpropyl cellulose (HPC) for magnetically guided drug delivery system with a capability of thermo-responsive controlled release. The composites are fabricated by a synthesis of Fe-Pt nanoparticles in a reaction solution containing HPC coated silica particles; Fe-Pt nanoparticles are grown on HPC deposited on the silica particles. The island-like composites of HPC and Fe-Pt NPs are observed to be densely deposited on the silica particles by transmission electron microscopy. Thermal responsiveness is evaluated by temperature-dependence of particle size distribution using dynamic light scattering; the thermal responsiveness is successfully confirmed even after the thermal history up to 533 K during synthesis.