Beckwith-Wiedemann syndrome with infantile hepatic hemangiomas

Abstract

 A 2-month-old female with Beckwith-Wiedemann syndrome, delivered at a gestational age of 25 weeks and birth weight 1, 083g, developed multiple liver masses. It was difficult to differentiate hepatoblastoma from hepatic hemangioma because she was too immature to perform a liver biopsy. We used, therefore, propranolol hydrochloride as a therapeutic and diagnostic treatment although it is not recommended to use for preterm infants in general. The patient showed a decrease tumor size significantly, which led to diagnosis as infantile hepatic hemangiomas.

 We suggest that propranolol hydrochloride may be useful to manage preterm infants with liver tumors suspected as infantile hepatic hemangioma.