Abstract
Background: Infants whose mothers have chronic abruption-oligohydramnios sequence（CAOS）have a poor outcome, but there are very few cohort studies from neonatologist.
Objective: To investigate the outcome of respiratory and growth and development in infants born from mothers complicated with CAOS.
Methods: Medical records of maternal and neonatal factors, and data on the neonatal short-term outcomes; the rate of chronic lung diseases, home oxygen therapy（HOT）, death, death due to cor palmonale, and long-term outcomes; height SD, weight SD, and total DQ values at 18 months corrected chronological age（c-CA）were examined.
Results: The neonates born from mothers with CAOS group had significantly high rate of chronic lung disease（94.1% vs 71.5%）, death due to cor palmonale（17.6% vs 0.6%）, and HOT or death due to cor palmonale（58.8% vs 19.6%）compared to the non-CAOS group. There were no significant differences in height SD, weight SD, or total DQ values at 18 months c-CA. After adjustment for background factors, the CAOS group was at significantly higher risk than the non-CAOS group for HOT or death due to cor palmonale（odds ratio［95% CI］ 3.85［1.27, 11.7］）.
Conclusion: Infants born from mothers with CAOS are expected to have a poor short-term respiratory prognosis but their growth and development are not significantly different from those of infants in the non-CAOS group. It is necessary to develop strategies for the prevention and treatment of chronic lung disease exacerbated by CAOS and to study longer term outcomes.
