Abstract
L-essential amino acid solutions (AMI-U, AMI-U-II) with hypertonic glucose (50-70%) were administrated to rabbits which were subjected to ligation of bilateral renal vessels. Same treatment was given to surgical patients with acute or chronic renal failure in an attempt to minimize azotemia. Prolongation of survival days was observed. Significant inhibition of elevation of blood urea nitrogen and serum potassium was observed in the experimental animals, in a condition that the non protein energy : nitrogen ratio (NEP kcal/Ng) of the solution ranges from 615 to 2, 052. The changes of guanidino-succinic acid (GSA) were measured in the control, AMI-U and AMI-U-II aministrated groups. The difference of elevation of GSA was not apparent among these three groups. Inhibition of elevation of blood urea nitrogen and serum creatinine was observed in adults and children with acute and chronic failure when NPE kcal/Ng of the solution was over 600.
