Abstract
The Spleen in neonate a higher microbicidal activity comparing with adult. Its function decreases as the age advances. If adult mouse spleen is activated by complete Freunds adjuvant, the spleen regaines its function. Therefore, a removal of the neonate or activated spleen will cause severe infection. Autotransplantation of the spleen was carried out in mice for protection of infection after splenectomy. The autotransplanted spleen easily regenerated in the subcutaneous region, peritoneal cavity, liver, kidney and brain. In the environments rich in vascularity such as kidney provided faster regeneration of the spleen. On day 14 after autotransplantation of the spleen, the T-cells and phagocytes of the autografts began to restore and microbicidal activity of the splenic cells occured. But the B-cells did not appear at the time. These results show that it is dangerous to remove the activated spleen and it is reasonable to autotransplant the spleen for protection of infection after splenectomy.
