Abstract
Liver damage formed by ligation of the bile duct secondarily causes splenomegaly. The spleen had the higher microbicidal activity with a decrease in the number of T-cells as seen in neonate. Removal of the spleen in this condition may cause postsplenectomy overwhelming infection as in neonate. The autografts of the mouse spleen regenerated faster in the host with liver damage and had the more phagocytes and higher microbicidal activity than the control group. These sesults suggest the usefulness of splenic autotransplantation after splenectomy in the host with liver damage.
