Abstract
The excretion of antibiotics in bile was studied in 5 patients with biliary atresia. Three of them were Kasai type I atresia and received cholecystostomy for initial bile drainage prior to the radical operation. Remaining 2 cases were received hepatic porto-jejunostomy by Roux-en-Y fashion with gastrojejunostomy. Consecutive excretion of antibiotics in bile was studied on 1 case with cholecystostomy at the early postoperative period. Antibiotics used for this study were followings; CPZ, LMOX, CMZ, AMK, and GM. All of these antibiotics were administered by intravenous one shot injection. Total amount of bile flow was determined using the catheter placed into the cholecystostomy or jejunostomy. The concentration of antibiotics in bile was measured using bioassay method. The results of the presented studies were followings; 1) The maximal concentration of CEPs and AGs in bile was higher than MIC to the causative organisms of the postoperative ascending cholangitis, whereas the clinical efficiency of antibiotics was influenced by the organisms in bile or intestine. 2) The excretion of antibiotics in bile was not influenced by the re-feeding of bile. 3) The result from consecutive pharmacokinetic study in early postoperative period indicated a relationship in excretion rate of antibiotics between bile and urine.
